OUR FLAGSHIP PRODUCT

First-in-class Small Drug
TET2 Activator

Research for a cancer-free life

ONR-001 is a first-in-class small molecule that allosterically and specifically activates TET2, a master epigenetic enzyme, causing tumor cells to enter a cell arrest stage and even die.

This unique method can be successfully used at all stages of the disease, from naïve primary tumors to recurrent resistant metastatic cancer – thus “making a world of difference“.

Oral Efficacy

  • Small molecule (MW400, LOGP 3,5)
  • Good potency (sub-mM)
  • Efficacy in animal models of cancer

Reaches the target

  • Crosses the cell and nuclear membranes
  • Activates TET2 in vivo and in the tumor tissue

Safe

  • Target Selectivity
  • High Acute & Chronic Tolerability in rodents
  • Clear PK/PD relationship